Ruparelia Laboratory: Muscle Growth, Regeneration and Ageing
Dr Avnika Ruparelia
+61 3 8344 8786
View Dr Ruparelia's latest Orcid publications listing here
The Ruparelia group's research investigates the biology of skeletal muscle ageing, including age-related muscle diseases. Our innovative research program seeks to identify the cellular, molecular and metabolic mechanisms that contribute to muscle wasting and the decline in muscle function, during ageing and disease, and to identify clinically relevant therapies to prevent or reverse these pathologies. Using the unique advantages of the zebrafish model, and a new experimental system – that of the African killifish, an extremely short-lived vertebrate – we are focused on four inter-linked themes:
- Regulation of muscle fibre atrophy: Why is there a loss in muscle mass during ageing and disease, and can we identify strategies to prevent it from occurring?
- Muscle stem cell dynamics during growth: Fish have an incredible capacity to grow by making new muscle cells throughout their life, which is something humans cannot do. Can we identify the processes regulating the addition of new muscle cells, and apply that to ageing and/or diseased muscle, and subsequently prevent wasting?
- Muscle regeneration: Muscle has a remarkable ability to regenerate following injury. How is this regulated and how can we boost the system during ageing and disease to improve the regenerative capacity of muscle?
- Metabolism in ageing. How do changes in metabolism contribute to ageing, muscle disease, and lifespan?
Prof. Gordon Lynch, Centre for Muscle Research, The University of Melbourne
Prof. Peter Currie, Australian Regenerative Medicine Institute
A/Prof Mirana Ramialison, Murdoch Children's Research Institute
Dr Peter Houweling, Murdoch Children's Research Institute
Prof. Christoph Englert, Leibniz Institute on Ageing
2022 - 2027 MRFF - Chronic Musculoskeletal Conditions in Children and Adolescents Grant Amount: $2.5M Year
This research project is available to PhD students, Masters by Research, Honours students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.
For project inquiries, contact our research group head.
Faculty Research Themes
School Research Themes
For further information about this research, please contact Head of Laboratory Dr Avnika Ruparelia
Department / Centre
Unit / Centre
MDHS Research library
Explore by researcher, school, project or topic.