Eckle Laboratory: MAIT Cell Biology and MR1-Mediated Antigen Recognition in Parasitic Disease and Allergy

• A/Prof Sidonia Eckle

  Head of Laboratory

  seckle@unimelb.edu.au
  

Research Overview

View A/Prof Eckle's latest publications listing here

The Eckle Lab investigates the role of mucosal-associated invariant T (MAIT) cells in parasitic diseases and allergy. A major focus is understanding the mechanisms that drive MAIT cell function, including the discovery of antigens and how they are recognised through the T cell receptor–MR1 axis. We combine mouse models and human samples with cellular, molecular and biochemical approaches to investigate MAIT cell responses. Our long-term goal is to harness MAIT cells for the development of new vaccines and immunotherapies.

Staff

Phoebe Dewar, Postdoctoral Researcher

Research Opportunities

This research project is available to PhD students, Masters by Research, Honours students, Master of Biomedical Science to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.

Research Outcomes

Corbett, A. J., McCluskey, J., Kjer-Nielsen, L., Chen, Z., Rossjohn, J., Patel, O., Birkinshaw, R. W., Eckle, S. B. G., Fairlie, D. P., Liu, L., & Mak, J. Y. W. (2019). Immunological reagents and uses therefor. U.S. Patent No. 10,245,262 B2 (WO 2015/149130). Google Patents: https://tinyurl.com/4vah3me5

Corbett, A. J., Eckle, S. B. G., Fairlie, D. P., Kjer-Nielsen, L., Liu, L., McCluskey, J., Patel, O., & Rossjohn, J. (2018). Immunological reagents and uses therefor. U.S. Patent No. 10,011,602 B2; Australian Patent No. 2013286823 B2 (WO 2014/005194). Google Patents: https://tinyurl.com/3nmuacn9