Darryl Johnson

I am an early career post-doctoral researcher with a continuing interest in immune cell responses, particularly receptor/antigen interactions, antigen recognition, and immune cell maturation and response development. Prior to commencing PhD studies, my primary focus was in T cell and NK cell antigen recognition, while my PhD research involved studying antigen-specific CD4+ T cells. This work involved studying the diversity of an antigen-specific CD4+ T cell repertoire selected in response to HSV-1 infection and the relationship between the affinity of TCR/pMHC-II interactions and CD4+ T cell effector functions. This work provided further information on the role that the affinity of antigen-specific TCR for pMHC-II complexes plays in shaping the immune responses of CD4+ T cells against viral pathogens. As an early career researcher, I have begun a research program investigating Innate-Like T cell (Natural Killer T (NKT) cells, Mucosal Associated Invariant T (MAIT) cells, and gdT cells) development and function. This work not only involves investigating NKT cell TCR recognition of self-glycolipids, but also involves a study of Innate-Like T cell development and function in situ through the generation new microscopy techniques.

  • Contact Details
    Department:Microbiology and Immunology
    Email: darrylj@unimelb.edu.au
    Phone:03 8344 5628
  • Current Research Focus

    Innate T cell biology

    Field of ResearchDescription
    110704Cellular Immunology
    110799Immunology not elsewhere classified
  • Key Skills
    • Fluorescence microscopy
    • Microscopy
    • Flow cytometry
    • Mouse models and cell culture
  • Looking to collaborate?

    Collaborators interested in studying immune responses in situ with fluorescence microscopy.