Putting cells through their paces


Pharmaceutical development depends on mouse models or on two-dimensional cultures for testing the potential effectiveness of a drug before progressing to expensive human trials. However, the system is far from perfect and failure rates when testing effectiveness in humans can be very expensive. 

Technology to create tissue and organs “on-a-chip” is at the forefront of medical research aimed at replicating what is going on in our bodies. But so far, while researchers around the world have been working to perfect the action of whole organs in a micro-fluidic chip environment, Professor Stewart says the accuracy of such models in being able to “fail” potential drugs is yet to be proven. “There are many aspects of organ-on-a-chip technology that remain a matter of belief rather than of evidence,” he says.

See the full  story in Pursuit.  The same story can be accessed from the News and Events page of Therapeutics Technologies Research Initiative (TTRI).