Welcome to the Melbourne Mouse Metabolic Phenotyping Platform (MMMPP)
The MMMPP manages and maintains a range of mouse metabolism specialist equipment. The aim of our platform is to expand the scope and quality of metabolic research equipment and techniques that are available to investigators.
We investigate ‘best practise’ methodologies, provide training, assist with experimental design and data analysis, and monitor the booking and service calendars for our equipment. We offer training and access to a TD-NMR minispec to analyse body composition, a Promethion Metabolic System for simultaneous recording of activity, food intake and energy expenditure, and to comprehensive functional and physiological investigative equipment.
Why study mouse metabolic function?
The prevalence of metabolic-related diseases is increasing at an alarming rate. Obesity predisposes affected individuals to life-threatening complications such as type 2 diabetes, cardiovascular disease, hypertension, stroke and fatty liver disease. Mice share many features of human metabolism and thus are often used for studying the pathophysiology of metabolic diseases, and with recent advances in molecular biology techniques the available range of transgenic mouse models is quickly expanding.
Studying the metabolic phenotypes of global and tissue-specific knock-out mice can provide increased genetic understanding. Additionally, analysis of metabolic function in various disease and treatment models can lead to new insights.
Acknowledgement of the platform in publications
When publishing research that has involved the MMMPP we respectfully request a mention in the paper’s acknowledgements section. This recognition provides the metrics needed to leverage the funding required to maintain and expand the platform’s capabilities.
‘This work was supported by infrastructure and technical assistance from the Melbourne Mouse Metabolic Phenotyping Platform (MMMPP) at the University of Melbourne.’*
*Haynes, V. R., Keenan, S. N., Bayliss, J., Lloyd, E. M., Meikle, P. J., Grounds, M. D., and Watt, M. J. 2019. Dysferlin deficiency alters lipid metabolism and remodels the skeletal muscle lipidome in mice. J Lipid Res. 60: 1350-64
The platform is governed by a Steering Committee and the day-to-day running is managed by the MMMPP Coordinator.
For platform information please contact the MMMPP Coordinator.