Ralph Laboratory: Drug Targets and Gene Regulation in Plasmodium falciparum
Stuart Ralph is interested in parasitic diseases, with a primary focus on the causative agent of severe malaria, Plasmodium falciparum.
The burden of disease-causing parasites is particularly high in developing countries, and inadequate resources are directed towards the development of much needed treatments. Complete genome sequences are available for many of these parasites, so a wealth of data is available from which to search for potential targets for chemotherapeutic interventions.
Stuart's interests lie in identifying and characterizing promising drug targets from Plasmodium falciparum and other parasites, as well as studying the modes of action and mechanisms of resistance for existing drugs.
Susann Herrmann (co-supervised with Leann Tilley)
Charlie Chua (co-supervised with Malcolm McConville)
V. Vern Lee
The Ralph laboratory is a member of a European Union FP7-funded consortium (Mephitis) of eight laboratories studying protein translation in the apicoplast and cystosol of Plasmodium in the search for potential targets for anti-malarial drugs.
Click here for the results of a PubMed search of Stuart's publications.
Click here for the results of a Google Scholar analysis of Stuart's publications.
- Aminoacyl-tRNA Synthetases Enzymes as Drug Targets
- Gene Regulation in Plasmodium falciparum
- Alternative Splicing in Human Parasites
Infection and Immunity
Areas of Excellence
Molecular Mechanisms of Disease,Therapeutics and Translation
For further information about this research, please contact
Dr Stuart Ralph.