Ralph Laboratory: Drug Targets and Gene Regulation in Plasmodium falciparum

Overview

Stuart Ralph is interested in parasitic diseases, with a primary focus on the causative agent of severe malaria, Plasmodium falciparum.

scheme showing malaria parasites invading human red blood cells

The burden of disease-causing parasites is particularly high in developing countries, and inadequate resources are directed towards the development of much needed treatments.  Complete genome sequences are available for many of these parasites, so a wealth of data is available from which to search for potential targets for chemotherapeutic interventions.

Stuart's interests lie in identifying and characterizing promising drug targets from Plasmodium falciparum and other parasites, as well as studying the modes of action and mechanisms of resistance for existing drugs.

Staff

Research Staff

Susann Herrmann (co-supervised with Leann Tilley)
Erin Lim

Graduate students

Charlie Chua (co-supervised with Malcolm McConville)
Kit Kennedy
Charisse Pasaje
Lee Yeoh

Honours Student

V. Vern Lee

photo of Ralph research group 2016

Funding

The Ralph laboratory is a member of a European Union FP7-funded consortium (Mephitis)  of eight laboratories studying protein translation in the apicoplast and cystosol of Plasmodium in the search for potential targets for anti-malarial drugs.

Research Publications

Click here for the results of a PubMed search of Stuart's publications.

Click here for the results of a Google Scholar analysis of Stuart's publications.