Establishing the effect of glycine/serine metabolism on skeletal muscle cell growth

Project Details

Skeletal muscle cell proliferation and growth require the production of building blocks for new cellular components (proteins, lipids and nucleic acids) as well the maintenance of cellular redox status. Observations in other cells suggest that the metabolism of the amino acid L-serine and its intermediate glycine can provide carbon units that satisfy many of these requirements. However, the cellular demand for L-serine is much greater than its uptake suggesting that the de novo production of L-serine is of critical importance to sustain cellular growth. Surprisingly, to date no detailed investigation of the role of L-serine biosynthesis in skeletal muscle has been performed and whether L-serine can support the production of biomass in growing muscle cells remains to be established.

Researchers

Dr René Koopman, Head of Laboratory

Marissa Caldow, Postdoctoral Fellow

Francesca Alves, Honours student

Funding

2018-2020 Duchenne Parent Project. Evaluating a sulforaphane-based nutraceutical to alleviate gastrointestinal dysfunction in DMD

2019-2021 ARC Development Grant. Mechanisms of age - related changes in amino acid signaling in skeletal muscle

Research Opportunities

This research project is available to PhD, Masters by Research, Honours, Master of Biomedical Science, Post Doctor Research students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.

Research Group

Koopman laboratory: Clinical nutrition and muscle metabolism


School Research Themes

Molecular Mechanisms of Disease, Cancer in Biomedicine, Therapeutics & Translation, Cell Signalling



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Physiology

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