Investigating the role of cachexia in the response to surgical tumour resection in mice

Project Details

Cancer cachexia is the progressive skeletal muscle wasting and weakness observed in 80% of cancer patients.

Cachexia reduces mobility and quality of life and in the most severe cases, can lead to death. Unfortunately, there are currently no effective treatments for cachexia, with one of the reasons being a lack of understanding of the cellular mechanisms responsible for this profound wasting and weakness. Chemotherapy and surgical interventions exist only to address primary tumour burden and the efficacy of both are dramatically limited by cachexia itself.

This project will use cell- and animal-based experiments to comprehensively identify how skeletal muscle responds to chemotherapy and surgical tumour resection and will lead to developing more targeted therapies to address cancer associated muscle wasting.

Researchers


Dr Kate Murphy
, Senior Research Fellow

Dr James Ryall, Senior Research Fellow

Dr Kristy Swiderski, Senior Research Fellow

Dr Justin Hardee, Postdoctoral Research Fellow

Dr Marissa Caldow, Senior Research Fellow

Audrey Chan, Research Support Officer

Jennifer Trieu, Research Assistant

Timur Naim, Research Assistant

Dylan Chung, Research Support Officer

Alaina Lee, Senior Research Assistant

Suzannah Read, Research Assistant

Students

Savant Thakur, PhD student

Francesca Alves, PhD student

John Nguyen, Masters student

Chloe Li, Masters student

Aundrea Quek, Masters student

Yichen Xue, Honours student

Funding

2019-2021 ARC Discovery Project. Mechanisms of age - related changes in amino acid signaling in skeletal muscle

2018-2021 NHMRC Project Grant. Rescuing the Dystrophin-Glycoprotein Complex to protect muscles from wasting conditions

2018-2020 Duchenne Parent Project. Evaluating a sulforaphane-based nutraceutical to alleviate gastrointestinal dysfunction in DMD

2017-2020 NHMRC Project Grant. Therapeutic potential of skeletal muscle plasticity and slow muscle programming for muscular dystrophy

2017-2020 NHMRC Project Grant. A simple method to improve stem cell transplant therapy

2017-2019 Cancer Council Victoria. Using novel Fn14 inhibitory antibodies to treat cardiac cachexia in cancer

2015-2019 ARC Discovery Project. Understanding the cellular cues that direct muscle stem cell specification

Research Opportunities

This research project is available to PhD, Masters by Research, Honours, Master of Biomedical Science, Post Doctor Research students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.

Research Group

Lynch laboratory: Basic and clinical myology



Faculty Research Themes

Cancer

School Research Themes

Cancer in Biomedicine, Molecular Mechanisms of Disease, Stem Cells



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Physiology

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