Skeletal muscle signal transduction related to exercise, metabolic disease and human health
-
Research Project Leader
Dr Benjamin Parker+61 3 8344 2925
Project Details
This project uses functional screening and proteomics to understand how signal transduction regulates metabolism. It aims to identify new therapeutic targets to treat diabetes and metabolic disease.
Research Opportunities
This research project is available to Honours students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.
Research Publications
*Hoffman, N.J., *Parker, B.L., Chaudhuri, R., Fisher-Wellman, K.H., Kleinert, M., Humphrey, S.J., Yang, P., Holliday, M., Trefely, S., Fazakerley, D.J., Stöckli, J., Burchfield, J.G., Jensen, T.E., Jothi, R., Kiens, B., Wojtaszewski, J.F., Richter, E.A., James, D.E. Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates. Cell Metab (2015) 22(5): 922 – 935. PMID: 26437602
Hingst, J.R., Bruhn, L., Hansen, M.B., Rosschou, M.F., Birk, J.B., Fentz, J., Foretz, M., Viollet, B., Sakamoto, K., Færgeman, N.J., Havelund, J.F., Parker, B.L., James, D.E., Kiens, B., Richter, E.A., Jensen, J., Wojtaszewski, J.F.P. Exercise-induced molecular mechanisms promoting glycogen supercompensation in human skeletal muscle. Mol Metab (2018) 16:24-34. PMID: 30093357
Kleinert, M., Parker, B.L., Jensen, T.E., Raun, S.H., Pham, P., Han, X., James, D.E., Richter, E.A., Sylow, L. Quantitative proteomic characterization of cellular pathways associated with altered insulin sensitivity in skeletal muscle following high-fat diet feeding and exercise training. Sci Rep. (2018) 8(1): 10723. PMID: 30013070
Whitham, M., Parker, B.L., Friedrichsen, M., Hingst, J.R., Hjorth, M., Hughes, W.E., Egan, C.L., Cron, L.N.N., Watt, K.I., Kuchel, R.P., Jayasooriah, N., Estevez, E., Petzold, T., Suter, C.M., Gregorevic, P., Kiens, B., Richter, E.A., James, D.E., Wojtaszewski, J.F.P., Febbraio, M.A., Quantitative proteomic analysis of the human extracellular vesicle proteome reveals a novel mechanism for tissue cross-talk during exercise. Cell Metabolism (2017) 27(1):237-251
Parker, B.L., Burchfield, J.G., Clayton, D., Geddes, T.A., Payne, R.J., Kiens, B., Wojtaszewski, J., Richter, E.A., James, D.E. Multiplexed temporal quantification of the exercise-regulated plasma peptidome. Mol Cell Proteomics (2017) 16(12):2055-2068. PMID: 28982716
Kleinert, M., Parker, B.L., Fritzen, A.M., Knudsen, J.R., Jensen, T.E., Kjøbsted, R., Sylow, L., Ruegg, M., James, D.E., Richter, E.A. Mammalian target of rapamycin complex 2 regulates muscle glucose uptake during exercise in mice. J Physiol (2017) 51(13): 7502-7510. PMID: 28464351
Needham, E.J., Parker, B.L., Burykin, T., James, D.E., Humphrey, S.J. Illuminating the dark phosphoproteome. Science Signaling (2019) 12(565). PMID: 30670635