Exploring new roles for the TGFβ signalling network as a key regulator of skeletal muscle in health and disease
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Research Project Leader
Associate Professor Paul Gregorevic+61 3 9035 7700
Project Details
The Transforming Growth Factor β (TGFβ) signalling network is one of the most important regulators of processes associated with skeletal muscle development, adaptation, and repair. However, many questions remain as to how this network is regulated in skeletal muscle in health and disease, how it controls processes that determine skeletal muscle characteristics, and how best to modulate network elements to prevent/treat muscle conditions. Combining gene delivery-based methods with cell culture and animal models and analyses of gene expression and protein regulation, this research theme seeks to examine novel processes that control the TGFβ network in skeletal muscle, and determine how unique components of the TGFβ network control skeletal muscle structure and function.
These discoveries will help to develop novel strategies for preventing/treating the loss of skeletal muscle mass and strength associated with disease and advancing age.
Researchers
A/Prof Paul Gregorevic, Head of Laboratory
Dr Adam Hagg, Research Fellow
Research Opportunities
This research project is available to Honours students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.
Research Publications
View A/Professor Gregorevic's latest PubMed publications listing here