Defining new roles for the Hippo signalling pathway in skeletal muscle

Project Details

The Hippo signalling pathway regulates skeletal muscle stem cell proliferation and terminal differentiation. Recently it has been determined that this pathway also operates as a vital post-natal regulator of the size of skeletal muscle fibres. How the Hippo pathway regulates muscle size, and what regulates the Hippo pathway in adult muscle fibres remains unknown.

This research program is using innovative gene therapy-based technologies to manipulate the Hippo pathway in vitro and in vivo to define (a) the critical targets genes controlled by Hippo signalling in skeletal muscle and (b) the essential elements that regulate Hippo pathway activity to control aspects of skeletal muscle biology.

Researchers

A/Prof Paul Gregorevic, Head of Laboratory

Dr Kevin Watt, Research Fellow

Dr Jonathan Davey, Research Fellow

Dr Rachel Thomson, Senior Research Assistant

Dr Hongwei Qian, Research Fellow

Alaina Lee, Senior Research Assistant

Students

Adam Hagg, PhD

Alastair Saunders, Masters

Jamie Ellis, Masters

Research Opportunities

This research project is available to PhD, Masters by Research, Honours, Master of Biomedical Science students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.

Research Publications

View A/Professor Gregorevic's latest PubMed publications listing here

Research Group

Gregorevic laboratory: Muscle Research and Therapeutics



Faculty Research Themes

Cancer, Neuroscience

School Research Themes

Cancer in Biomedicine, Biomedical Neuroscience, Molecular Mechanisms of Disease, Cell Signalling, Therapeutics & Translation



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Physiology

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