Traumatic brain injury
Traumatic brain injury (TBI) represents the major cause of death in young individuals in industrialised countries. Despite the improvement of neurosurgical procedures as well as critical care management, morbidity and mortality are still high and approximately 25% of these patients remain with permanent disabilities becoming a familiar, social and economic burden for society. A better understanding of events occurring in the brain after traumatic brain injury is essential to identify ways to limit the damage and ultimately improve the outcome. The advent of microarray technology has given the researcher the ability to potentially identify the regulation of thousands of genes and enables a broad assessment of gene changes after traumatic brain injury. With the backing of the Victorian Trauma Foundation we have undertaken a microarray study to determine a temporal profile of gene changes in the brain after TBI. This data is being used to understand the molecular pathways that are changed in the brain after TBI.
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