Passive antibody immunity for use in combination microbicides
he production of high quality HIV Env gp140 trimers as antigen in the Purcell laboratory are used to vaccinate pregnant cows. During the third trimester the concentration in the colostrum of IgG is increased where soon after labour this is collected to yield up to 1kg of IgG. The colostrum has a high binding capacity as well as broad neutralizing activity against diverse strains of HIV-1. In collaboration with Kent, it was shown that these antibodies also engage human FcR and initiate the processes of antibody dependent cellular cytotoxity (ADCC) in vitro. These unique antibodies are then used to try and prevent transmission in the mucosae of large animals as well as co-formulating with a combination of drugs and other compounds as a combination HIV microbicide.
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