Understanding the regulation of tissue-resident memory T cell development
Laura’s group’s work has shown that tissue-resident memory T cells (Trm) are phenotypically and functionally distinct to memory T cells in the circulation. They have found that Trm development is a multistep process that requires the action of several molecules, and that these cells acquire a unique transcriptional profile during their differentiation. Using several different infectious models including Influenza, herpes simplex virus, Listeria and LCMV, Laura’s group is investigating the regulatory cues and mechanisms that govern Trm cell development in different tissues, with a focus on the transcriptional networks that regulate commitment to this immune cell lineage.
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