The role of resident memory T cells in barrier immunity and autoimmune disease
Infections are commonly acquired through barrier tissues such as the skin, gut and lung, hence establishing memory CD8+ killer T cell populations at these sites is critical for effective immune protection. While most memory T cells circulate in the blood, a distinct lineage, termed tissue-resident memory T cells (Trm), resides and remains in peripheral tissues. Laura’s group’s work has shown that these cells form a defensive barrier providing immediate local control of viral infection. Using methods including flow cytometry, histology and intravital 2-photon microscopy, current work focuses on how Trm cells respond following secondary infection, and they are developing novel strategies to boost Trm cell responses, which aim to facilitate the development of strategies to exploit these cells in vaccination settings. Work in the laboratory also aims to understand the role of Trm cells in autoimmune conditions such as psoriasis, and Laura’s group is investigating new approaches to eliminate pathological cells from peripheral tissues.
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