Delineating how CD4 T cells ‘help’ establishing effective killer T cell responses
Resolution of virus infections relies on the orchestrated activation of dendritic cells (DC), CD4 T cells and killer T cells. We have known for some time that CD4 T cells contribute to killer T cell immunity, but how CD4 T cells, DC and killers interact in vivo is still unclear. Using a model of peripheral virus infection, we found that CD4 T cells contributed to CTL immunity by amplifying the IFN-α/β-induced provision of IL-15 by DC to CTL. Building upon these novel findings, we are currently dissecting the molecular mechanisms.
Faculty Research Themes
School Research Themes
For further information about this research, please contact the research group leader.
Department / Centre
Unit / Centre
MDHS Research library
Explore by researcher, school, project or topic.