Deciphering the relative contributions of different dendritic cells to killer T cell responses
Continuing our endeavor to resolve the role of dendritic cells (DC) in virus infections, this project investigates the relative contributions of different DC subtypes to killer T cell priming and examines the molecular pathways involved (direct vs. cross-presentation). Utilizing in vivo models that remove the capacity of cells to directly present viral antigen, we found that robust virus-specific killer T cell responses depend on cross-presentation. We are currently delineating the underlying mechanisms.
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