Role of innate signals in inducing protective T cell immunity
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Although it is clear that the innate and the adaptive immune system are inextricably linked, precisely how these two arms of the immune system interact still remains unclear. This project examines how specific pathogen sensing pathways contribute to effective killer T cell responses. We are specifically interested in type I interferons and how these are induced and regulated in dendritic cells through molecules or molecule complexes, such as toll-like receptors, STING and inflammasomes.
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