Tissue-resident memory T cells in the skin
|Associate Professor Scott Muelleremail@example.com||+61 3 8344 9044||View page|
Protection from viral infections that target peripheral tissues such as the skin requires coordinated recruitment of pathogen-specific T lymphocytes into the tissue where they function to defeat the virus. Following the resolution of HSV-1 infection or inflammation in the skin, tissue-resident memory (Trm) CD8+ T cells reside for long periods in the epidermis where they can provide enhanced protection from reinfection. These tissue-resident T cells display a unique dendritic morphology and a slow pattern of tissue surveillance (Movie 1). We are examining how these Trm cells are formed, persist and respond following secondary infection.
Movie 1: Tissue-resident CD8 T cells (green) migrating in the epidermis of the skin.
Collagen (SHG), blue.
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