Mechanisms underlying early generation of human T cell memory

• 
  Project Leader
  Associate Professor Katherine Kedzierska

  kkedz@unimelb.edu.au

  View researcher's webpage

  +61 3 8344 3384

Project Details

Though immunological memory is of pivotal importance for vaccine development and immunotherapy, the molecular and differentiation pathways central to the generation of (particularly) human CD8+ T-cell memory are poorly understood. Here, we aim to:

1. establish the key factors driving the early establishment of influenza-specific T cell memory;
2. To define molecular processes involved in CD27-mediated co-stimulation of human T cells. As memory is crucial for protection against recurrent infections, this work will provide novel insights into the generation and efficacy of human T cell memory populations and inform effective CD27-mediated stimulation for immunotherapy.