Mechanisms underlying early generation of human T cell memory
Researcher
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Project Leader Associate Professor Katherine Kedzierska
+61 3 8344 3384
Project Details
Though immunological memory is of pivotal importance for vaccine development and immunotherapy, the molecular and differentiation pathways central to the generation of (particularly) human CD8+ T-cell memory are poorly understood. Here, we aim to:
- establish the key factors driving the early establishment of influenza-specific T cell memory;
- To define molecular processes involved in CD27-mediated co-stimulation of human T cells. As memory is crucial for protection against recurrent infections, this work will provide novel insights into the generation and efficacy of human T cell memory populations and inform effective CD27-mediated stimulation for immunotherapy.