A universal vaccine against influenza A
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A long standing interest of this laboratory is in developing vaccines which induce CD8+ T cell responses against the conserved regions of influenza in anticipation that we can develop a universal vaccine against the virus. We are investigating the ways in which HLA-diversity can be addressed using multi-epitope or protein-based vaccines in order to generate a CD8+ T cell-based vaccine which is effective in the population at large. We are also determining the features of CD8+ T cell function, location and magnitude that are associated with long-term protection against influenza A infection.
Figure 1: Dr Brendon Chua and Mr Toshiki Sekiya
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