Autophagy and Norovirus replication

Lead Researcher Email Number Webpage
Professor Jason Mackenzie +61 3 9035 8376 View page

Project Details

We are also interested in the role autophagy plays in MNV-1 replication. Autophagy is a cellular mechanism used to recycle proteins and degrade pathogens as a method of prolonging cell life. We have since discovered that MNV-1 infection induces autophagy but does not utilize the autophagosomal membranes to facilitate replication. Various techniques have been used in this project including; immunofluorescence, western blotting, qPCR, plaque assays and live cell imaging. Further analyses will examine the effects of autophagy inducing and inhibiting compounds on MNV-1 replication and what implications these results will reveal about how MNV-1 is able to manipulate cells.


Ms Tanya O'Donnell (PhD student)


Justine Mintern (University of Melbourne) and Skip Virgin (Washington University School of Medicine, USA)

Research Group

Mackenzie laboratory: Intracellular virus replication and innate immunity

Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity, Molecular Mechanisms of Disease

Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Microbiology and Immunology

Unit / Centre

Mackenzie laboratory: Intracellular virus replication and innate immunity