Mackenzie laboratory: Intracellular virus replication and innate immunity
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Our overall objectives are to investigate and unravel the replication mechanism of two positive-stranded RNA viruses (West Nile virus [a flavivirus] and Mouse Norovirus [a Norovirus]) that are highly pathogenic to humans and cause outbreaks of encephalitis and gastroenteritis. Our aims are to determine how and where these viruses replicate within infected cells and what host components/organelles are "used and abused" by the virus. We aim to correlate this abuse of host with the pathogenic outcomes associated with viral infection. In conjunction with these studies we are investigating how viruses can evade our immune system and in particular how viruses can bypass the antiviral activities of our first line of defence; the innate immune system.
- Autophagy and Norovirus replication
- Norovirus replication and innate immunity
- Visualization and formation West Nile Virus replication complexes
- West Nile Virus replication and cellular stress responses
- Role of cellular lipids during Flavivirus replication
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For further information about this research, please contact Head of Laboratory Professor Jason Mackenzie
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