NKT cells, MAIT cells, CD1-restricted T cells and HIV
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NKT cells are a small but very important lymphocyte population in blood that possess potent antiviral and antitumor activities. In collaboration with Dr Godfrey and colleagues, we recently showed NKT cells are depleted during SIV and SHIV infection of monkeys. 100 * We are investigating strategies to enhance the biologic utility of NKT cells in fighting HIV. 150 * We are also studying an interesting population of cells called Mucosal-associated Invariant T cells (MAIT cells)176 * and the effect of HIV and SIV on these important cells that fight bacterial infections. In collaboration with Dr Dan Pellici and colleagues, we are investigating the CD1-restricted T cells and their role in HIV and other infections.
Figure 1: NKT cell population in Macaca Nemestrina blood
* superscript number links to a specific publication in the chronological listing on Stephen's blog
Professor Stephen Kent, Dr Jen Juno, Prof Dale Godfrey, Dr Dan Pellici, Ms Thakshila Amarasena.
NHMRC Program and project grants.
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