Villadangos laboratory: Antigen presenting cells & molecules that initiate T cell immunity against pathogens and cancer
Our laboratory studies the first event that triggers adaptive immune responses: the presentation of pathogen or tumor antigens to T cells by Dendritic Cells, B cells and Macrophages. We are characterizing the development, regulation and impairment of antigen presenting cells by pathogens, inflammatory mediators and tumours. We are also dissecting the biochemical machinery involved in antigen capture, processing and presentation. We use this knowledge to understand how T cell-dependent immunity is initiated and maintained, and apply it to design better vaccines and immunotherapies against infectious agents and cancer.
Our lab uses cutting-edge biochemistry, cell biology and immunological techniques to unravel important immunological problems. Techniques include:
- Experimental models of viral, bacterial and malaria infection
- Analysis and development of immunotherapies against cancer
- CRISPR-Cas9 for specific gene targeting and whole-genome library screens
- Flow cytometry
- Immunofluorescent microscopy
- Intra-vital microscopy
- Proteomics and transcriptomics
- Immunological assays
Gerry (Geraldine) Healey | E-mail: firstname.lastname@example.org
Jacinta Wubben (Monash University) | E-mail: email@example.com
Tian Zehua | E-mail: firstname.lastname@example.org
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- Harnessing dendritic cells for vaccine development
- Immuno-paralysis following severe infections or trauma
- Joining the immunotherapy revolution: Adoptive cell therapy against cancer
- Function of MARCH ubiquitin ligases
- How MR1 molecules present a novel family of antigens to MAIT cells
- Autophagy: a Novel Pathway of Antigen Presentation in Dendritic Cells
- The role of glucose metabolism and O-GlcNAc glycosylation in the regulation of immunity
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For further information about this research, please contact Professor Jose Villadangos
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