How does ageing effect antibody responses?

Project Details

Antibodies are a vital component of the immune response required for protection and control of infectious diseases. However, large changes can occur to the quality of an antibody response as a person grows older. One of the reasons for this change is glycosylation, where sugar structures are added to the antibody. Different glycan structures can determine how well the antibody activates surrounding innate immune cells to attack and eliminate invading pathogens. Intriguingly, within humans, large antibody glycan changes are observed within infants and elderly, which may contribute to why they are more susceptible to infection. This project aims to further understand the effect of aging upon antibody responses using non-human primate models.

Researchers

Kevin J Selva, Research Officer

Ester Lopez, Research Assistant

Collaborators

Dr Nicholas Scott, University of Melbourne

Professor Stephen Kent, University of Melbourne

Associate Professor Shelby O'Connor, University of Wisconsin-Madison

Research Opportunities

This research project is available to Masters by Research, Honours, Master of Biomedical Science students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.

Research Group

Chung laboratory: Investigating the role of functional antibodies against Mycobacterium tuberculosis



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Microbiology and Immunology

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