Barrow laboratory: Tissue immunosurveillance strategies

Research Overview

View Dr Alexander Barrow's latest ORCID publications listing here.

Photo of the Barrow group

The Barrow laboratory is interested in mechanisms of tissue immunosurveillance, in particular a new immunological recognition strategy termed ‘growth factor surveillance’. Growth factors (GFs) are over-expressed by cancer cells to promote tumour growth. Pathogens, especially viruses, also encode GF homologues that are required for host infectivity. We first showed the immune system evolved activating receptors to sense aberrant GF expression by cancers and pathogens. The Barrow lab’s goal is to understand how the immune system recognises GF expression by tumours and infected cells with the ultimate aim of exploiting these pathways for cancer immunotherapy and the development of new vaccines. More recently, we have become interested in how immune cells may use GF surveillance for immunosurveillance of the brain, such as glioblastoma, a devastating high grade glioma of poor survival.

Staff

Dr Patrick Constantinescu, Research Officer

Dr Nazanin Ghazanfari, Research Officer

Alexander James Sedgwick, Masters student

Yuhan Sun, Masters student

Funding

MRFF Accelerated Research Program 'Role of the NKp44-PDGF-DD axis in Glioblastoma'

Research Opportunities

This research project is available to PhD, Masters by Research, Honours to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.