Barrow laboratory: Tissue immunosurveillance strategies
Dr Alexander David Barrow
View Dr Alexander Barrow's latest ORCID publications listing here.
The Barrow laboratory is interested in mechanisms of tissue immunosurveillance, in particular a new immunological recognition strategy termed ‘growth factor surveillance’. Growth factors (GFs) are over-expressed by cancer cells to promote tumour growth. Pathogens, especially viruses, also encode GF homologues that are required for host infectivity. We first showed the immune system evolved activating receptors to sense aberrant GF expression by cancers and pathogens. The Barrow lab’s goal is to understand how the immune system recognises GF expression by tumours and infected cells with the ultimate aim of exploiting these pathways for cancer immunotherapy and the development of new vaccines. More recently, we have become interested in how immune cells may use GF surveillance for immunosurveillance of the brain, such as glioblastoma, a devastating high grade glioma of poor survival.
Dr Patrick Constantinescu, Research Officer
Dr Nazanin Ghazanfari, Research Officer
Alexander James Sedgwick, Masters student
Yuhan Sun, Masters student
MRFF Accelerated Research Program 'Role of the NKp44-PDGF-DD axis in Glioblastoma'
This research project is available to PhD, Masters by Research, Honours students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.
- Molecular basis for growth factor surveillance in natural killer cells
- Molecular basis for growth factor surveillance in plasmacytoid dendritic cells
- Immunosurveillance pathways in brain cancer
- Student projects
Faculty Research Themes
School Research Themes
For further information about this research, please contact Head of Laboratory Dr Alexander David Barrow
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