Lymphoid stromal cells and control of immunity to infection and cancer

Project Details

The lymphoid tissues (spleen and lymph nodes) are constructed of a complex microarchitecture that is supported by networks of endothelial and mesenchymal stromal cells. The T cell zones in the spleen and lymph nodes are supported by a complex network of stromal cells (Movie 1). Little is known of the phenotype of these stromal cell subsets and how they can influence the immune cells they regularly interact with. We are examining how lymphoid stromal cells contribute to the functions of the secondary lymphoid organs during immune responses to viral infections and in response to blood cancers and metastatic tumours.

Movie 1: The stromal cell network in the T cell zone of a lymph node.

Research Publications

Alexandre YO, Mueller SN. Stromal cell networks coordinate immune response generation and maintenance. Immunol Rev. 2018; 283(1): 77-85. doi: 10.1111/imr.12641. PMID: 29664562

Mueller SN, Germain RN. Stromal cell contributions to the homeostasis and functionality of the immune system. Nat Rev Immunol. 2009; 9(9): 618-629. doi: 10.1038/nri2588. PMID: 19644499

Gregory JL, Walter A, Alexandre YO, Hor JL, Liu R, Ma JZ, Devi S, Tokuda N, Owada Y, Mackay LK, Smyth GK, Heath WR, Mueller SN. Infection Programs Sustained Lymphoid Stromal Cell Responses and Shapes Lymph Node Remodeling upon Secondary Challenge. Cell Rep. 2017; 18(2): 406-418. doi: 10.1016/j.celrep.2016.12.038. PMID: 28076785

Mueller SN, Matloubian M, Clemens DM, Sharpe AH, Freeman GJ, Gangappa S, Larsen CP, Ahmed R. Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection. Proc Natl Acad Sci U S A. 2007; 104(39): 15430-5. doi: 10.1073/pnas.0702579104. PMID: 17878315

Mueller SN, Hosiawa-Meagher KA, Konieczny BT, Sullivan BM, Bachmann MF, Locksley RM, Ahmed R, Matloubian M. Regulation of homeostatic chemokine expression and cell trafficking during immune responses. Science. 2007; 317(5838): 670-4. PMID: 17673664

Research Group

Mueller laboratory: Visualising the immune system in action

Faculty Research Themes

Infection and Immunology

School Research Themes

Cellular Imaging & Structural Biology

Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Microbiology and Immunology

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