The innate immune system in the respiratory tract

Project Details

Introduction of infectious disease agents such as influenza A virus into the respiratory tract and pulmonary system results in the enlistment of immune cells, including neutrophils and macrophages, resulting in elevation of inflammatory and Th1 cytokines including IFN-γ and TNF-α. This immune activity is associated with broad spectrum, and antigen-independent, protection against subsequent challenge with mild and virulent influenza viruses. We are currently determining the mechanisms that underlie this phenomenon with a view to finding methods of reducing transmission of influenza at a population level.

Research Group

Jackson laboratory: Synthetic vaccine design

Faculty Research Themes

Infection and Immunology

School Research Themes

Cardio-Respiratory, Molecular Mechanisms of Disease

Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Microbiology and Immunology

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