Cellular trafficking and male fertility
Development of functional sperm requires control not only of gene expression but also correct regulation of protein and lipid membrane trafficking. Processes as diverse as stem cell differentiation, specialised germ cell cytokinesis and development of elongated spermatozoa all have specific requirements for protein localisation and membrane re-arrangement. We are examining the roles of nuclear importation and vesicular trafficking in sperm development.
James Heaney, PhD student
John Qi, MSc student
Professor Kate Loveland, Hudson Institute of Medical Research
Professor Julie Brill, The Hospital for Sick Kids, Toronto, Canada
- Brill, JA, Hime, GR, Scharer-Schuksz, M, Fuller, MT. () A phospholipid kinase regulates actin organization and intercellular bridge formation during germline cytokinesis. Development 2000; 127: 3855-3864.
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