Molecular mechanisms that contribute to bone marrow pain
A number of ion channels and receptors are emerging as important modulators of the activity of peripheral bone marrow nociceptors. Identifying these regulators of nerve activity in bone nociceptors and better understanding their role in generation of bone pain could open up avenues for development of tools to selectively manipulate pain originating from bone. In this project, we will use a variety of techniques to explore roles for a number of different ion channels and receptors in generating and/or maintain bone pain. Depending on the particular ion channel or receptor that is being explored, students can expect to gain experience in working with an in vivo electrophysiological bone-nerve preparation, neuroanatomical tracing and immunohistochemistry, small animal handing, anaesthesia, surgery and dissection.
Jenny Thai, Research assistant
Sara Nencini, PhD student
Abdulhakeem Alamri, PhD student
Associate Professor James Brock
Associate Professor Michael Barrington
Associate Professor Stuart Mazzone
Dr. Alice McGovern
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