Is the “shed” form of Sez-6 proteins responsible for their synapse-promoting effects?
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Certain proteins, including Sez-6 family proteins, can be located either on the surface of neurons or shed from the surface of neurons by the actions of particular proteases. Secreted proteins and shed forms of transmembrane proteins are then able to act on nearby neurons to influence their growth and the formation of synaptic connections. This project will compare the effects of secreted and shed forms of Sez-6 family proteins on the growth of neuronal arbors (dendrites, axons) and synaptogenesis.
- Dr Jenny Gunnersen
- Dr Kathryn Munro
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