The taxonomy of enteroendocrine cells and their innervation

Researcher

Project Details

The hormone secreting cells of the gastrointestinal tract are essential for normal gut health and are targets for therapy.  The organisation of these cells and their classification is undergoing revolutionary change

In this study you will use immunohistochemical methods, along with high resolution fluorescence microscopy and computer-aided image analysis to compare the distributions of EEC, their innervation and the colocalisation of hormones in human and in the model species of mouse, rat and pig.

The EEC signal to and receive signals from the nervous system, but their relationships with nerves are poorly understood.

The hormone secreting cells of the gastrointestinal tract are essential for normal gut health and are targets for therapy. Enteroendocrine cells (EEC) receive input signals from nerves and also signal to nerves.  They are targeted for the treatment of disease, including diabetes. Recent studies from our and other labs show that the distributions of these cells are substantially different between species and that there are complex patterns of colocalisation of the hormones.  A particular focus is cells containing 5-hydroxytryptamine.

Researchers

Project supervisor:

  • Professor John Furness

Project members:

  • Dr Rachel McQuade, Mr Martin Stebbing, Dr Shanti Diwakarla

Research Publications

Cho, HJ, Kosari, S, Hunne, B, Callaghan, B, Rivera, LR, Bravo, DM, Furness, JB:  Differences in hormone expression patterns of K-L enteroendocrine cells in the mouse and pig small intestine and colon.  Cell Tissue Res 359, 693-698 (2015)

Diwakarla, S, Fothergill, LJ, Fakhry, J, Callaghan, B, Furness, JB: Heterogeneity of enterochromaffin cells within the gastrointestinal tract.  Neurogastroenterol Motil. 29: e13101 (2017)

Research Group

Furness laboratory: Digestive physiology and nutrition



Faculty Research Themes

Neuroscience



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Anatomy and Neuroscience

Unit / Centre

Furness laboratory: Digestive physiology and nutrition


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