Nutrition: The control of gut hormone release by nutrients
Control of gut hormone release is important to diabetes, weight control and digestive health. We have made the discovery that hormones that are in the same cells are in separate storage vesicles. Our observation raises the strong possibility that the release of GI hormones that are colocalised in EEC cells, could be differentially controlled.
In this project you will work with a team to investigate the separate subcellular locations and the mobilisation of vesicles that contain 2 or more hormones in mouse enteroendocrine cells. Naturally-occurring and synthetic stimulants of nutrient receptors on enteroendocrine cells will be used to promote vesicle translocation and release.
- Professor John Furness, Dr Rachel McQuade
- Dr Shanti Diwakarla, Dr Martin Stebbing, Linda Fothergill, Ada Koo
Furness, JB, Rivera, LR, Cho, H‐J, Bravo, DM, Callaghan, B: The gut as a sensory organ. Nature Rev. Gastroenterol. Hepatol 10, 729-740 (2013).
Cho H-J, Robinson ES, Rivera LR, McMillan PJ, Testro A, Nikfarjam M, Bravo DM & Furness JB. Glucagon-like peptide 1 and peptide YY are in separate storage organelles in enteroendocrine cells. Cell Tissue Res 357, 63-69 (2014).
Fothergill, LJ, Callaghan, B, Hunne, B, Bravo, DM, Furness, JB: Co-storage of enteroendocrine hormones evaluated at the cell and subcellular levels in male mice. Endocrinology 158, 2113-2123 (2017) doi: 10.1071/AN17276
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