Post-translational control of cell fate decisions
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Cell fate decisions are fundamental during the development of multicellular organisms. They affect all aspects of a cell’s behaviour including morphology, migration, proliferation, and specialized functions such as contraction, detoxification, and hormone production and are therefore the foundation for the development of a multicellular organism. Arguably, one of the most unique cell fate decisions during mammalian development forms the basis of male vs. female identity. While progress has been made in understanding the role of transcriptional regulation, the influence of post-translational modification is poorly understood.
We have shown that NEDD4-mediated ubiquitination is absolute necessary for mammalian sex determination. In this project we are testing the hypothesis that post-translational modifications, and specifically ubiquitination, control cell fate decisions that play a critical role in sex development.
The understanding of the post-translational modification in the regulation and function of gonad-specific proteins will contribute to advance our understanding of cell fate decision during gonad development and will ultimately inform about post-translational regulation driving organogenesis, cell fate decisions and cellular reprogramming during embryonic development.
Simon Windley, PhD student
Prof Sharad Kumar, Centre for Cancer Biology, Adelaide
Dr Quenten Schwarz, Centre for Cancer Biology, Adelaide
Dr Natasha Harvey, Centre for Cancer Biology, Adelaide
A/Prof Serge Nef, University of Geneva, Switzerland
ARC Discovery grant: “Post-translational control, of cell fate decisions”
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