Role of long noncoding RNAs in neurological disorders
Thousands of regions in our DNA have been linked to a multitude of traits and diseases. However, many of these regions don't contain any known protein coding genes, though most of these "empty" regions do express long noncoding RNAs (lncRNAs). This raises the possibility that some of these lncRNAs play a role in disease risk and other human traits.
What role do lncRNAs play in conferring risk for, or protection to, human neurological disorders? To answer this we use extremely sensitive techniques such as RNA CaptureSeq to characterise lncRNAs in human brain and stem-cell derived neurons and follow up studies to investigate lncRNA functions.
This approach has the potential to determine the underlying mechanisms that link genomic regions to human brain disorders and the function and impact of lncRNAs on human disease.
Prof Paul Harrison, University of Oxford, UK
A/Prof Liz Tunbridge, University of Oxford, UK
Dr Zameel Cader, University of Oxford, UK
Dr Wilfried Haerty, Earlham Institute, UK
Bartonicek N, Clark MB, Quek XC, Torpy JR, Pritchard AL, Maag JLV, Gloss BS, Crawford J, Taft RJ, Hayward NK, Montgomery GW, Mattick JS, Mercer TR, Dinger ME. (2017) Intergenic disease-associated regions are abundant in novel transcripts. Genome Biol 18(1): 241.
Clark MB*, Mercer TR*, Bussotti G, Leonardi T, Haynes KR, Crawford J, Brunck ME, Lê Cao K, Thomas GP, Chen WY, Taft RJ, Nielsen LK, Enright AJ, Mattick JS, Dinger ME (2015). Quantitative gene profiling of long-noncoding RNAs with targeted RNA sequencing. Nature Methods. 12(4):339-342. (* Joint first authors).
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