Improving bladder health after spinal cord injury
Spinal cord injury severely affects the function of the urinary bladder, with loss of voluntary voiding and a greatly increased risk of bladder complications including infections. In this project we are investigating the mechanisms by which spinal cording injury causes damage to epithelial lining of the bladder (the urothelium). The urothelium plays a critical role in resisting invasion of the bladder wall by bacteria. In addition, recent evidence demonstrates that the urothelium plays a central role in regulating the activity of the bladder. The objective of our studies is to devise strategies that protect the urothelium from adverse effects of spinal cord injury.
Nicole Kerr, Research Assistant
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