Lipidome profiling of inflammatory biomarkers for beta cell autoimmunity in type 1 diabetes
Type 1 diabetes (T1D) is an autoimmune disease that is characterized by progressive immune cell-mediated destruction of insulin-producing pancreatic ß cells.
Detection of early stages of ß cell autoimmunity prior to the fully developed pathology would markedly improve the success of therapeutic strategies designed to prevent T1D.
It has recently become evident that in addition to cytokine and pro-inflammatory protein pathways, bioactive lipid mediated signaling also plays an important role in tissue inflammation and immune cell signaling.
Here, in a project funded by the Juvenile Diabetes Research Foundation and in an ongoing collaboration with researchers at Michigan State University, we are developing mass spectrometry lipidomic approaches to identify complex lipids and bioactive lipid mediators in ß cells and blood serum that can serve as biomarkers for the development of ß cell autoimmunity and destruction, and progression to T1D.
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