Cheng laboratory: Molecular enzymology of protein kinases and phosphatases involved in human diseases

Researcher

Research Overview

Protein phosphorylation and dephosphorylation are the most prevalent post-translational modifications regulating the structures and functions of cellular proteins in a wide spectrum of cellular processes, ranging from metabolism to cell fate control.

Even though protein kinase genes constitutive only 2% of the genomes in most eukaryotes, more than 30% of total cellular proteins are phosphorylated. Furthermore, aberrant regulation of protein kinases and phosphatases contributes to pathogenesis and progression of many diseases.

In light of the significant role played by protein kinases phosphatases in cell regulation and disease pathogenesis, research in my group focuses on the biochemical basis of their regulation and function.

Specifically, we focus on the protein kinases and phosphatases involved in cancer formation and progression, and acute and chronic neurological diseases associated with neuronal cell death.

Staff

Daisy Sio Seng Lio, Research Assistant
Dr M Iqbal Hossain, Research Assistant
Mohd A. Kamaruddin, Graduate Student
Ashfagul Hague, Graduate Student
Haiyan Wei, Visiting PhD student
Mai Tran, Honours Student
Gabriella Fotinopoulos, Honours Student

Research Publications

Click here for the results of a Google Scholar analysis of Heung-Chin's publications.

Research Projects

This Research Group doesn't currently have any projects



Faculty Research Themes

Cancer

School Research Themes

Cancer in Biomedicine, Molecular Mechanisms of Disease, Cell Signalling



Key Contact

For further information about this research, please contact Head of Laboratory Associate Professor Heung-Chin Cheng

Department / Centre

Biochemistry and Molecular Biology

Unit / Centre

Cheng laboratory: Molecular enzymology of protein kinases and phosphatases involved in human diseases


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