Cheng laboratory: Molecular enzymology of protein kinases and phosphatases involved in human diseases
Protein phosphorylation and dephosphorylation are the most prevalent post-translational modifications regulating the structures and functions of cellular proteins in a wide spectrum of cellular processes, ranging from metabolism to cell fate control.
Even though protein kinase genes constitutive only 2% of the genomes in most eukaryotes, more than 30% of total cellular proteins are phosphorylated. Furthermore, aberrant regulation of protein kinases and phosphatases contributes to pathogenesis and progression of many diseases.
In light of the significant role played by protein kinases phosphatases in cell regulation and disease pathogenesis, research in my group focuses on the biochemical basis of their regulation and function.
Specifically, we focus on the protein kinases and phosphatases involved in cancer formation and progression, and acute and chronic neurological diseases associated with neuronal cell death.
Daisy Sio Seng Lio, Research Assistant
Dr M Iqbal Hossain, Research Assistant
Mohd A. Kamaruddin, Graduate Student
Ashfagul Hague, Graduate Student
Haiyan Wei, Visiting PhD student
Mai Tran, Honours Student
Gabriella Fotinopoulos, Honours Student
Click here for the results of a Google Scholar analysis of Heung-Chin's publications.
- Deciphering the role of c-Src tyrosine kinase in excitotoxic neuronal death during ischemic stroke
- Protein kinases involved in pathogenesis of Parkinson’s disease
- Biochemical and structural basis of the tumour suppression mechanism of CSK-homologous kinase
- Development of self-reporting fluorescent chemosensor peptide substrates as molecular sensors
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School Research Themes
For further information about this research, please contact Associate Professor Heung-Chin Cheng
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