Cell biology of membrane receptors regulating the serum half-life of therapeutic proteins
The neonatal Fc receptor (FcR) plays a critical role in regulating the half-live of a range of serum proteins, including IgG, in the adult. Our research, in collaboration with CSL, is investigating the membrane recycling pathway of the neonatal Fc receptor, information which is critical for the optimizing the life span of therapeutic proteins.
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