Alternative splicing in human parasites
Next generation sequencing has revealed that an unexpectedly high proportion of mammalian genes undergo alternatively splicing to produce multiple transcript isoforms.
We have recently shown that alternative splicing is also widespread in the human parasites Plasmodium (causative agent of malaria) and Toxoplasma, (causative agent of toxoplasmosis). We are now investigating whether this mechanism is necessary for parasites differentiating between human and invertebrate life-stages. We will apply novel long-read sequencing techniques to establish the impact of alternative splicing on whole transcripts in a variety of human and veterinary parasites. We will also investigate the implications of alternative splicing on generation of proteome diversity. This is a collaborative project with Associate Professor Aaron Jex at the Walter and Eliza Hall institute of Medical Research.
Associate Professor Aaron Jex, Walter and Eliza Hall institute of Medical Research
This is a collaborative funded by a discovery project grant from the Australian Research Council (Grant DP160100389)
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