Murray laboratory: Myelin biology

Research Overview

View Dr Murray's latest publications listing here and Find an Expert profile here

Myelin is the insulating sheath wrapping around many axons in the peripheral (PNS) and central nervous system (CNS). It is essential for the rapid and efficient transmission of neural signals along the axons, and provides metabolic and trophic support to the axons that it surrounds. Human demyelinating diseases, such as Multiple Sclerosis (MS), have a devastating impact on quality of life. It is the failure of the nervous system to repair myelin after a demyelinating insult that leads to disease progression and increasing disability. In addition, myelin damage is a common pathological feature of many neurodegenerateive diseases. However, there is currently an incomplete understanding of the molecular and cellular events that initiate, promote and maintain the interactions between neurons and glial cells that are vital for myelination in both the PNS and CNS.

Our laboratory is particularly interested in understanding the molecular cues that are vital for myelination during development, and myelin repair after injury as well as developing new therapeutics for promoting repair after myelin injury. We use a variety of molecular, cellular, biochemical, genetic and confocal imaging techniques in combination with behavioural analyses and animal models of demyelinating disease to investigate these events.

Honour Projects 2021

PROJECT #1: CAN MIMETICS OF BDNF PROMOTE REMYELINATION AFTER INJURY?

In CNS demyelinating diseases, oligodendrocytes (the cells that generate myelin) progressively die. However, they possess an innate capacity to regenerate themselves and repair the lost myelin. Unfortunately, over time and repeated demyelinating events, this capacity for regeneration and repair reduces. We have identified that BDNF plays an important role in myelin development and repair. Building on these findings, we have developed novel low molecular weight peptides designed to selectively mimic the agonist properties of BDNF.  This project is multifaceted in that it aims to use in vitro assays to optimise and characterise novel next-generation peptides, and use in vivo assays to investigate whether these novel BDNF mimetic peptides can promote myelin repair using animal models of nervous system demyelination.

PROJECT #2: ANALYSIS OF MYELIN SPECIFIC TRANSCRIPTION FACTORS.

The myelin sheath -- a multi-layer membrane that wraps around many nerves in the central nervous system (CNS) -- is critical for optimal brain function. Myelin sheaths are made by cells called oligodendrocytes and most myelin sheaths are formed in early postnatal development, but new sheaths can be added throughout life in response to learning or brain injury. However, the molecular mechanisms that regulate these dynamic changes in myelin sheath growth have not been fully identified. The overall aim of this project is to identify and characterise novel molecular mechanisms that control myelin sheath growth in the CNS. We will use innovative interdisciplinary methods to identify novel ways that signaling pathways, protein interactions and transcription factors are activated to control oligodendrocyte development and myelination.

Staff

Associate Professor Simon Murray, Head of Laboratory

Rhiannon Wood, Research Assistant

Madeline Nicolson, PhD student

Sangwon Yoo, PhD student

Georgina Craig, PhD student

Collaborators

Prof Erica Fletcher, Dept Anatomy & Neuroscience, University of Melbourne

Prof Trevor Kilpatrick, Dept Anatomy & Neuroscience, University of Melbourne

Prof Barry Hughes, School of Mathematics and Statistics, University of Melbourne

A/Prof Tony Hughes, Dept. Pharmacology & Therapeutics, University of Melbourne

Prof Anthony Hannan, The Florey Institute of Neuroscience and Mental Health Research

Dr Tim Auman, The Florey Institute of Neuroscience and Mental Health Research

Dr Suzanne Hodgkinson, South Western Sydney Clinical School, University of NSW

Dr Ben Emery, Oregon Health& Science University (USA)

Prof Rashmi Bansal, University of Connecticut (USA)

Prof Fang Wu, Shanghai JiaoTong University (China)

Dr David Gonsalvez, Monash University

Funding

2018-2021 ARC Discovery Project Grant. How neurons regulate the myelinating process

2018-2021 US Department of Defense Investigator-Initiated Research Award. Developing a Novel Neurotrophin-Based Strategy to Promote Myelin Repair in Multiple Sclerosis

2019-2020 MS Research Australia Project Grant. Promoting myelin repair in a refractory environment in vivo

2019-2021 MS Research Australia Project Grant. How neurons regulate cortical and subcortical remyelination?

2016-2018 NHMRC Project Grant. Novel strategies to promote myelin repair in the brain

2014-2017 NHMRC Project Grant. Developing a new strategy for treating peripheral demyelinating neuropathy

Research Outcomes

"Mimicking a cure", Australian Life Scientist, 14 August 2013

“Kiss Goodbye to Multiple Sclerosis” - to support “World MS Day”. The Age, edited by Ms. Kate Hagan, 26 May 2010

Research Projects

This Research Group doesn't currently have any projects



Faculty Research Themes

School Research Themes

Biomedical Neuroscience, Molecular Mechanisms of Disease, Cell Signalling, Cellular Imaging & Structural Biology, Therapeutics & Translation



Key Contact

For further information about this research, please contact Head of Laboratory Associate Professor Simon Murray

Department / Centre

Anatomy and Physiology

Unit / Centre

Murray laboratory: Myelin biology

MDHS Research library
Explore by researcher, school, project or topic.