EMT regulators in intestinal and germline stem cells
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Project Leader
Professor Gary Hime+ 61 3 834 45796
Project Details
We have shown that members of the Snail family of transcriptional repressors are required in diverse stem cell populations. This role has been conserved through evolution of animals as Snail family members can be found in stem cells from Drosophila to mouse.
This project involves using genetically modified Drosophila or mouse strains to identify how these proteins regulate stem cell numbers and control the production of differentiated progeny cells.
Researchers
Franca Casagranda, Research Assistant
Nicole Dominado, PhD student
Elena Savva, Masters (MSc) student
Yoshana Fonseka, Honours student
Collaborators
Associate Professor Helen Abud, Monash University Biomedicine Discovery Institute
Professor D Leanne Jones, University of California at Los Angeles
Research Publications
- Horvay K, Jarde T, Casagranda F, Perreau VM, Haigh K, Nefzger CM, Akhtar R, Gridley T, Berx G, Haigh JJ, Barker N, Polo JM, Hime GR*, Abud HE*. Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium. EMBO Journal 2015; 34(10): 1319-35.
*joint senior authors - Voog J, Sandall SL, Hime GR, Resende LP, Loza-Coll M, Aslanian A, Yates JR 3rd, Hunter T, Fuller MT, Jones DL. ( Escargot restricts niche cell to stem cell conversion in the Drosophila testis. Cell Reports 2014; 7(3): 722-34.
- Horvay K, Casagranda F, Gany A, Hime GR, Abud HE. Wnt Signaling Regulates Snai1 Expression and Cellular Localization in the Mouse Intestinal Epithelial Stem Cell Niche. Stem Cells Dev 2011; 20(4): 737-745.