Cellular trafficking and male fertility
-
Project Leader
Professor Gary Hime+ 61 3 834 45796
Project Details
Development of functional sperm requires control not only of gene expression but also correct regulation of protein and lipid membrane trafficking. Processes as diverse as stem cell differentiation, specialised germ cell cytokinesis and development of elongated spermatozoa all have specific requirements for protein localisation and membrane re-arrangement. We are examining the roles of nuclear importation and vesicular trafficking in sperm development.
Researchers
Nicole Siddall, Postdoctoral Researcher
Franca Casagranda, Research Assistant
James Heaney, PhD student
John Qi, MSc student
Caitlin van Ree, Honours student
Collaborators
Professor Kate Loveland, Hudson Institute of Medical Research
Professor Julie Brill, The Hospital for Sick Kids, Toronto, Canada
Research Publications
- Brill, JA, Hime, GR, Scharer-Schuksz, M, Fuller, MT. () A phospholipid kinase regulates actin organization and intercellular bridge formation during germline cytokinesis. Development 2000; 127: 3855-3864.