A stem cell therapy to reverse the effects of spinal cord injury

Project Details

Spinal cord injury results in loss of control over limb function, causing paraplegia or tetraplegia.  Bowel dysfunction (constipation associated with overflow fecal incontinence) is a further debilitating consequence of most spinal cord injuries. Loss of bowel control means most spinally injured people are incontinent and unable to make voluntary bowel movements.  A significant number of spinally injured people become socially reclusive because of the embarrassment of fecal incontinence.

In recent years there has been a degree of success with the use of stem cells to restore spinal cord connection in animals and humans.  Mature neurons of the enteric nervous system have a greater plasticity than mature neurons of the central nervous system.  Thus, after lesioning in mature animals, enteric neurons regrow and form appropriate functional connections.

In this project you will investigate whether enteric neurons, or enteric neurons plus mesenchymal stem cells, enhance spinal cord repair, and bowel and hind-limb control.

Researchers

  • Project supervisors: Professor John Furness, Dr Lincon Stamp,
  • Project members: Dr Ruslan Pustovit, Ms Enie lei, Ms Lauren Patten

Collaborators

Dr Mark Habgood

Research Opportunities

This research project is available to Masters by Research, Master of Biomedical Science to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.

Research Publications

Ellis, AG, Zeglinski, PT, Brown, DJ, Frauman, AG, Millard, M, Furness, J.B.: Pharmacokinetics of the ghrelin agonist capromorelin in a single ascending dose phase 1 safety trial in spinal cord injured and able bodied volunteers. Spinal Cord 53, 103-108 (2015).

Research Group

Furness laboratory: Digestive physiology and nutrition



Faculty Research Themes

Infection and Immunology



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Anatomy and Neuroscience

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