Dr. Katrina Binger is a Research Fellow in the Department of Biochemistry and Molecular Biology at the University of Melbourne. She completed her PhD in Biochemistry 2009, before changing research fields to undertake postdoctoral training on projects investigating chronic diseases such as hypertension, diabetes and inflammation. In 2012 she was awarded a NHMRC Early Career Fellowship (CJ Martin) to continue her research at the Max-Delbruck Centre for Molecular Medicine in Berlin, Germany. Here, she demonstrated that high dietary salt (sodium chloride, NaCl) has diverse effects on the activation of macrophages: pro-inflammatory ""M1"" responses were augmented by high salt, while anti-inflammatory ""M2"" mechanisms were suppressed (Binger et al JCI 2015; Jantsch et al Cell Metab 2015). This work provided evidence that high dietary salt may lead to an overall imbalance in immune homeostasis. Since returning to Australia and the University of Melbourne in 2016, Dr. Binger has been establishing cross-disciplinary approaches to understand how changes in the composition of tissue microenvironments affect immune cell function via metabolism.
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Current Research Focus
Cellular metabolism and macrophage responses
Field of Research Description 060104 Cell Metabolism 110707 Innate Immunity
- Flow cytometry
- Seahorse bioanalyser
- Mice models leishmaniasis