Innovative tool predicts Buruli ulcer outbreaks in Victoria
Researchers have developed a surveillance system capable of detecting elevated risks of Buruli ulcer outbreaks in Victoria thanks to possum ‘poo’ – a breakthrough in the fight against the disease.
Once considered an exotic bacterial infection, Buruli ulcer has become an important public health problem in Victoria, with the state now considered one of the most endemic areas for the disease globally.
Over the past five years, Beating Buruli ulcer in Victoria, a world-first, collaborative research project led Professor Tim Stinear, (Dept of Microbiology & Immunology Doherty Institute), has made significant progress in understanding how the disease is transmitted and what can be done to prevent infections from the flesh-eating bacteria.
In addition to confirming the role Australian native possums play in human outbreaks of Buruli ulcer, a recent study published in eLife described a ground-breaking surveillance tool created by the Beating Buruli ulcer in Victoria research team with the potential to control the disease.
Comparing data from possum ‘poo’ analysis to epidemiological data over time, researchers identified a significant spatial correlation between clusters of M. ulcerans positive possum excreta and clusters of human Buruli ulcer cases.
Our data showed that outbreaks of Buruli ulcer coincided with a high number of possums carrying the bacteria. While it is something we’ve been suspecting for a while, this finding categorically confirms the important role of Australian native possums in the transmission of the bacterium to humans.
Following this significant finding and using the possum ‘poo’ data, the team developed the first-ever computer modelling program capable of predicting locations and times of increased Buruli ulcer transmission risk in Victoria.
The team developed a mathematical model that uses the GPS coordinates of where the M. ulcerans bacteria has been detected in possum excreta, and identifies the households that are most likely to be at risk from Buruli ulcer in the coming months.
The surveillance system represents major progress towards the control and elimination of Buruli ulcer in southeast Australia.
“This sophisticated early warning system could play a significant role in preventing cases of Buruli ulcer in Victoria by alerting the public and local healthcare providers to the increased risk of infection,” Professor Stinear said.
The Victorian Department of Health is a key collaborator in this project and, together, we are discussing how they can use this program to inform the design and delivery of targeted public health interventions to prevent human cases.
This article was originally published on 24 May 2023 by the Peter Doherty Institute for Infection & Immunity (Doherty Institute).
The story also featured in SBS News.
The Doherty Institute is a joint venture between The University of Melbourne and The Royal Melbourne Hospital.