Case Study 1
Case Study 2
Case Study 3
Publications from the MMMPP
Dysferlin deficiency alters lipid metabolism and remodels the skeletal muscle lipidome in mice
Haynes, V. R., Keenan, S. N., Bayliss, J., Lloyd, E. M., Meikle, P. J., Grounds, M. D., and Watt, M. J. 2019. Dysferlin deficiency alters lipid metabolism and remodels the skeletal muscle lipidome in mice. J Lipid Res. 60: 1350-64
Websites of interest
A web application for indirect calorimetry analysis.
- CalR generates customisable time, bar and regression plots.
- Useful for analysis of Promethion data sets.
Publications of interest
Progress and challenges in analyzing rodent energy expenditure
Fernández-Verdejo, R., Ravussin, E., Speakman, J.R., Galgani, J.E. 2019. Progress and challenges in analyzing rodent energy expenditure. Nature Methods. PMID: 31391589.
Whole-body energy expenditure is the summed metabolic activities of tissues and, to remove the influence of body size, ratios of energy expenditure to body mass are often applied but can generate spurious differences. In 2011, a group of experts proposed adoption of ANCOVA for the analysis of metabolic rate but, seven years later, analyses based on ratios remain the most frequent. We discuss some of the barriers to adopting better analytical procedures.