Case Study 1
Haynes, V., et al. Metabolic phenotype of a model of muscular dystrophy
Case Study 2
Thorough in vivo muscular phenotype. Coming soon!
Case Study 3
Websites of interest
A web application for indirect calorimetry analysis.
- CalR generates customizable time, bar and regression plots.
- Useful for analysis of Promethion data sets.
Progress and challenges in analyzing rodent energy expenditure
Fernández-Verdejo, R., Ravussin, E., Speakman, J.R., Galgani, J.E. 2019. Progress and challenges in analyzing rodent energy expenditure. Nature Methods. PMID: 31391589.
Whole-body energy expenditure is the summed metabolic activities of tissues and, to remove the influence of body size, ratios of energy expenditure to body mass are often applied but can generate spurious differences. In 2011, a group of experts proposed adoption of ANCOVA for the analysis of metabolic rate but, seven years later, analyses based on ratios remain the most frequent. We discuss some of the barriers to adopting better analytical procedures.
Dysferlin deficiency alters lipid metabolism and remodels the skeletal muscle lipidome in mice
Haynes, V. R., Keenan, S. N., Bayliss, J., Lloyd, E. M., Meikle, P. J., Grounds, M. D., and Watt, M. J. 2019. Dysferlin deficiency alters lipid metabolism and remodels the skeletal muscle lipidome in mice. J Lipid Res. In press.