Equipment & Services

Equipment List [select section to view]

  • Comprehensive metabolic phenotyping equipment

    Metabolic cage system

    Promethion 16 cage system, Sable, Nevada, USA

    • Simultaneously measures physical activity (with or without wheel), food/water intake and indirect gas exchange calorimetry. Non-invasive recording of O² consumption and CO² production in individual mice allows calculation of the respiratory exchange ratio (RER) and energy expenditure.

    Metabolic Parameters

    Indirect calorimetry was used to measure and compare metabolic parameters in two groups of male, age-matched C57BL/6 mice over a 24-hr period, with one group receiving treatment injection and the control group receiving a vehicle. The graphs above show data for oxygen consumption (A and B), carbon dioxide production (C and D), respiratory quotient (E and F), energy expenditure (G and H), food intake (I and J), and ambulatory activity (K). Results are shown as mean ± SEM.


    Minispec MRI scanner

    LF50H Minispec, Bruker, Germany

    • Fat and lean mass measured non-invasively in awake mice using time delay nuclear magnetic resonance (TD-NMR) spectroscopy

    body composition

    Body composition for lean and fat mass was measured in age-matched male mice fed either a chow or high-fat diet. Results are shown as mean ± SEM.

  • Functional testing equipment

    Anaesthesia delivery system

    SomnoSuite vapouriser, Kent Scientific, Connecticut, USA

    • Uses room air to deliver isoflurane at a low flow rate in proportion to the animal's size

    Electrocardiogram (ECG) recorder

    ECGenie, Massachusetts, USA

    • Heart electrical function in conscious mice

    HR.            HR Variation

    Heart function was assessed in aged-matched male mice in either a sedentary control group or a trained group,  measuring for changing in heart rate (beats per minute) and heart rate variation (beats per minutes). Results are shown as mean ± SEM.


    Glucose monitors (hand-held)

    Accu chek glucometer, Roche, Basel, Switzerland

    • Glucose and insulin tolerance tests

    Laser Doppler

    MoorLDI, Devon, UK

    • Hind limb circulation including quantification of blood flow during restriction and recovery

    Oxygen bomb calorimeter

    CAL3K-U, DDS Calorimeters, Gauteng, South Africa

    • Caloric content of specialty diets and faecal samples

    Faecal energy and Digestive Efficiency

    Bomb calorimetry was used to assess faecal energy and digestive efficiency in age-matched male mice in either a control group or drug treatment group. Results are shown as mean ± SEM.

  • Muscle and exercise studies equipment

    Acceleration/velocity race track

    Acceleration/Velocity Race Track, Columbus Instruments, Ohio, USA

    • 2.5 m enclosed track with 24 photobeam “curtains” to assess speed

    Gait analysis instrumentation

    DigiGait, Mouse Specifics, Massachusetts, USA

    • Performs gait analysis using ventral plane videography

    Grip strength meter

    GT3 Grip Strength Test, Bioseb, Vitrolles, France

    • Foreleg muscular strength

    Rota-rod motor coordination

    LE8205 Accelerating Rotarod, PanLab, Harvard Apparatus, USA

    • To measure motor coordination, balance and fatigue

    Spontaneous running wheel

    0297-16, Columbus Instruments, Ohio, USA

    • 16 home cages with wheels and tracking software for exercise vs. sedentary studies

    Treadmill

    Exer 3/6 treadmill with incline, Columbus Instruments, Ohio, USA

    • Exercise training with 6 lanes, adjustable speed and optional incline

Pricing

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Bookings

For equipment bookings please contact the MMMPP Coordinator.

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